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OCR: by Neurofibromatosis type I is characterise cafe-au-lait spots and the development ty may neurofibromas. Central precocious pube mas or often occur in association with optic gli ary area neurofibromas of the hypothalamicu (Fig. 13.32). This disorder has an autoso i incidence dominant pattern of inheritance, with a scoliosis, ormalities of one in thirty-four thousand. Bone ab such as cysts, hemihypertrophy, bowing skull and facial defects, dumbbell-shape and Lesch neurogliomas of the spinal nerve roots, ith other nodules of the eyes, and an association neoplasms such as central nervous syst nas, astrocytomas, ependymomas, meningio neurofibromas, neurofibrosarcomas, C rhabdomyosarcomas and nonlymphocy cytomas leukaemia, are also found. Phaeochrom may also develop in affected adults.